lamivudine side effects

Torres RA, Lin RY, Lee M, Barr MR "Zidovudine-induced leukocytoclastic vasculitis." Headache, dizziness, nausea, diarrhea, or trouble sleeping may occur. Description: Lamivudine, a synthetic nucleoside analogue, is phosphorylated into the body to the active 5'-triphosphate metabolite.It inhibits RNA- and DNA-dependent polymerase activities of reverse transcriptase via DNA chain termination. 1. Learn more about Dolutegravir & Abacavir & Lamivudine Lamivudine (3tc) (Epivir; Epivir HBV) is a drug prescribed for the treatment of HIV infection and hepatitis B infection. Do not take more or less of it or take it more often than prescribed by your doctor. Lamivudine / 3TC TABLETS AND ORAL SOLUTION. In an asymptomatic HIV infection study, asthenia and malaise were reported in 10.1% and 55.6% (using 1500 mg) and 8.6% and 53.2% (using 500 mg) of patients using zidovudine, respectively. Many other medications may also interact with lamivudine and zidovudine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Wright JM, Sachdev PS, Perkins RJ, Rodriguez P "Zidovudine-related mania." epivir. For Healthcare Professionals General. HCPs who received occupational PEP with triple-drug regimen, AZT+3TC+Lpv/r, experienced different side effects, and the tolerability and safety of PEP regimen were good in this cohort. Epivir (lamivudine)." Sahai J, Conway B, Cameron D, Garber G "Zidovudine-associated hypertrichosis and nail pigmentation in an HIV-infected patient." Incidence was higher in patients with mild laboratory abnormalities at baseline. 2014;127(14):2632-6. Incidence was higher in patients with mild laboratory abnormalities at baseline. "New once-daily HIV combination better tolerated." J Intern Med 231 (1992): 317-8, 21. "Product Information. One patient with preexisting hepatitis B developed acute hepatic failure 2 weeks after starting zidovudine therapy. Available for Android and iOS devices. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Take efavirenz, lamivudine, and tenofovir exactly as directed. … AIDS 21 (2007): 268-269, 11. Common Questions and Answers about Lamivudine side effects. See below for a comprehensive list of adverse effects. Redistribution/accumulation of body fat has been reported with antiretroviral therapy; causality has not been established. Bluish or brownish-black discoloration of nails has developed during the first 1 or 2 months of zidovudine therapy and usually disappeared within 2 months if the drug is discontinued. 7. [Ref], Very common (10% or more): Insomnia and other sleep disorders (up to 11.6%), -Common (1% to 10%): Sleep disorders, insomnia, -Rare (0.01% to 0.1%): Anxiety, depression, loss of mental acuity, -Frequency not reported: Mania, confusion, grandiosity, emotional lability, nervousness[Ref]. If appropriate, initiation of anti-hepatitis B therapy may be warranted. [Ref], -Frequency not reported: Urinary hesitancy, dysuria, polyuria[Ref]. [Ref], Common (1% to 10%): Anorexia and/or decreased appetite, Postmarketing reports: Hyperglycemia, redistribution/accumulation of body fat, lactic acidosis, -Very rare (less than 0.01%): Lactic acidosis, -Postmarketing reports: Hyperlactatemia (common), lactic acidosis (rare), redistribution/accumulation of body fat, -Rare (0.01% to 0.1%): Lactic acidosis (without hypoxemia), -Frequency not reported: Redistribution/accumulation of body fat, hyperlactatemia, -Frequency not reported: Redistribution/accumulation of body fat (including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement, "cushingoid appearance"), increased blood lipid levels, increased glucose levels[Ref], Common (1% to 10%): Skin rashes, sweating, fungal skin infection, acne and folliculitis, viral skin infection, Postmarketing reports: Alopecia, erythema multiforme, Stevens-Johnson syndrome, urticaria, -Common (1% to 10%): Sweating/diaphoresis, fungal skin infection, acne and folliculitis, viral skin infection, -Rare (0.01% to 0.1%): Nail and skin pigmentation, urticaria, -Frequency not reported: Lipoatrophy, skin and nailbed pigmentation changes, toxic epidermal necrolysis, leukocytoclastic vasculitis (with eosinophilia and fever), nail hyperpigmentation (rarely accompanied by mucocutaneous pigmentation or hypertrichosis), body odor[Ref]. Lamivudine / zidovudine systemic 150 mg / 300 mg (TV TV L2 L2), We comply with the HONcode standard for trustworthy health information -, Blistering, peeling, or loosening of the skin, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue, muscle pain, spasms, stiffness, or cramping, red skin lesions often with a purple center, sores, ulcers, or white spots in the mouth or on the lips or tongue, tingling, burning, numbness, or pain in the hands, arms, feet, or legs, darkening of the skin and mucous membranes, swelling of the breasts or breast soreness in both females and males, swollen, painful, or tender lymph glands in the neck, armpit, or groin. Ann Intern Med 116 (1992): 311-3. [Ref], Very common (10% or more): Headache (up to 35.1%), neuropathy (up to 12.4%), dizziness (up to 10.4%), Frequency not reported: Syncope, taste perversion, Postmarketing reports: Paresthesia, peripheral neuropathy, seizures, -Rare (0.01% to 0.1%): Peripheral neuropathy/neuropathy, paresthesia, -Very common (10% or more): Headache, dizziness, -Common (1% to 10%): Neuropathy, paresthesia, somnolence, taste perversion, -Frequency not reported: Generalized seizures, status epilepticus, vertigo, Wernicke's syndrome, hearing loss, hyperalgesia, tremor, syncope[Ref], Very common (10% or more): Nausea (33%), diarrhea (18%), nausea and vomiting (13%), abdominal discomfort and pain (up to 11.3%), Common (1% to 10%): Abdominal cramps, dyspepsia, elevated amylase, fungal gastrointestinal (GI) infection, GI discomfort and pain, gaseous symptoms, vomiting, Postmarketing reports: Oral mucosal pigmentation, stomatitis, pancreatitis, -Common (1% to 10%): Nausea, vomiting, abdominal discomfort and pain or cramps, diarrhea, -Uncommon (0.1% to 1%): Pancreatitis, abnormal pancreatic enzymes, -Rare (0.01% to 0.1%): Elevated serum amylase, -Very common (10% or more): Nausea, GI pain, diarrhea, vomiting, -Common (1% to 10%): Abdominal discomfort and pain, fungal GI infection, GI discomfort and pain, gaseous symptoms, elevated amylase, dyspepsia, -Rare (0.01% to 0.1%): Oral mucosa pigmentation, pancreatitis, -Frequency not reported: Constipation, dysphagia, tongue edema, eructation, bleeding gums, rectal hemorrhage, lip edema, mouth ulcer[Ref]. Taking efavirenz, lamivudine, and tenofovir at bedtime may make certain side effects less bothersome. Truvada, tenofovir, lamivudine, emtricitabine, Atripla, Stribild, Complera, Epzicom. AIDS 13 (1999): 1659-67, 14. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Before using Tenofovir/lamivudine/efavirenz Tablet, inform your doctor about your current list of medications, over the counter products (e.g. 2. Call your doctor for medical advice about side effects. In this study, back pain, arthralgia, muscle spasm, twitch, and myopathy were reported in less than 5% of patients using zidovudine. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Lamivudine side effects. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue lamivudine / zidovudine and are co-infected with HIV-1 and HBV. In an asymptomatic HIV infection study, nausea, vomiting, and constipation were reported in 57.3%, 16.4%, and 8.1% (using 1500 mg) and 51.4%, 17.2%, and 6.4% (using 500 mg) of patients using zidovudine, respectively.[Ref]. In an advanced HIV disease study, headache (42%), somnolence (8%), dizziness (6%), paresthesia … Other side effects include: neutropenia. Combivir (lamivudine-zidovudine)" Glaxo Wellcome, Research Triangle PK, NC. It is much better tolerated than interferon. In the early symptomatic HIV disease study, nausea (61%), vomiting (25%), and dyspepsia (6%) were reported with zidovudine. Elevated amylase (greater than 2 times the upper limit of normal [2 x ULN]) has been reported in 4.2% of patients using lamivudine plus zidovudine and 1.5% of patients using zidovudine. Although not all of these side effects may occur, if they do occur they may need medical attention. In 1 zidovudine study, myalgias and elevated CPK occurred in 8% of treated patients with a CD4 cell count less than 200/mm3, and in none of the patients with higher CD4 cell counts. Occasionally, neutropenia and anemia reported with lamivudine were severe. You may report side effects to FDA at 1-800-FDA-1088. If you notice any other effects, check with your healthcare professional. Check with your doctor immediately if any of the following side effects occur while taking lamivudine / zidovudine: Some side effects of lamivudine / zidovudine may occur that usually do not need medical attention. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Am J Med 86 (1989): 469-70, 26. In an advanced HIV disease study, headache (42%), somnolence (8%), dizziness (6%), paresthesia (6%), and taste perversion (5%) were reported with zidovudine; only headache was reported at a significantly greater rate than placebo. Advertising revenue supports our not-for-profit mission. Portions of this document last updated: Feb. 01, 2021. Anemia, neutropenia, and leukopenia were reported more often with higher doses (1200 to 1500 mg/day) and in patients with advanced HIV disease (especially with poor bone marrow reserve at baseline) and particularly in those with CD4 cell counts less than 100/mm3. Ann Intern Med 110 (1989): 85-6, 22. Epivir (lamivudine) side effects list for healthcare professionals The following adverse reactions are discussed in other sections of the labeling: Exacerbations of hepatitis B. Lactic acidosis and severe hepatomegaly with steatosis. This site complies with the HONcode standard for trustworthy health information: verify here. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. It contains lamivudine, nevirapine, and stavudine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Dubin G, Braffman MN "Zidovudine-induced hepatotoxicity." Medically reviewed by Drugs.com. Rarely, lamivudine has caused severe (sometimes fatal) liver problems and a buildup of lactic acid in the blood (lactic acidosis). These side effects may go away during treatment as your body adjusts to the medicine. In this study, acne, pruritus, urticaria, nail pigmentation, and body odor were reported in less than 5% of patients using zidovudine. In an advanced HIV disease study, lymphadenopathy was reported in less than 5% of patients using zidovudine.[Ref]. This content does not have an Arabic version. Drug interactions, and dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication. In an advanced HIV disease study, changes in liver function tests (including increased AST levels) was reported in less than 5% of patients using zidovudine. Incidence was higher in patients with mild laboratory abnormalities at baseline. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Dolutegravir & Abacavir & Lamivudine - Get up-to-date information on Dolutegravir & Abacavir & Lamivudine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Lamivudine/nevirapine/stavudine (3TC/NVP/d4T) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. Gastro-intestinal disorders: Pancreatitis, upper abdominal pain, … [Ref], Postmarketing reports: Sensitization reactions (including anaphylaxis), -Frequency not reported: Sensitization reactions (including anaphylaxis)[Ref], In an advanced HIV disease study, urinary frequency, urinary hesitancy, dysuria, and polyuria were reported in less than 5% of patients using zidovudine. Gradon JD, Chapnick EK, Sepkowitz DV "Zidovudine-induced hepatitis." Ann Intern Med 112 (1990): 145-6, 28. Side effects have been reported with lamivudine and zidovudine, administered separately or together. It is either used by itself or along with other antiretrovirals. In this study, seizures, vertigo, hearing loss, hyperalgesia, tremor, and syncope were reported in less than 5% of patients using zidovudine. In an advanced HIV disease study, nausea (46%), GI pain (20%), diarrhea (12%), vomiting (6%), and dyspepsia (5%) were reported with zidovudine; only nausea was reported at a significantly greater rate than placebo. In an advanced HIV disease study, amblyopia and photophobia were reported in less than 5% of patients using zidovudine. Serious side effects of lamivudine include a buildup of lactic acid in the blood (lactic acidosis), severe liver problems, and inflammation of the pancreas (pancreatitis) in children at risk for developing pancreatitis. ).Some health conditions may make you more susceptible to the side-effects of the drug. This content does not have an English version. In this study, redistribution/accumulation of body fat was reported in less than 5% of patients using zidovudine. pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue right upper abdominal or stomach pain and fullness Health Canada. (4/8/2015): 6. O 0, 3. "Severe liver toxicity in postexposure prophylaxis for HIV infection with a zidovudine, lamivudine and fosamprenavir/ritonavir regimen." Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract.Delayed absorption by ingestion w/ food. Incidence of neutropenia increased in patients with low neutrophil counts, hemoglobin levels, and serum vitamin B12 levels at baseline. These serious side effects may occur more often in women and obese patients. [Ref], In an advanced HIV disease study, vasodilation was reported in less than 5% of patients using zidovudine. [Ref], In an advanced HIV disease study, insomnia (5%) was reported with zidovudine at a significantly greater rate than placebo. Last updated on July 6, 2020. Human Services. AIDS 5 (1991): 1395-6, 25. Along with its needed effects, lamivudine / zidovudine may cause some unwanted effects. Hepatic decompensation (some fatal) has been reported in patients coinfected with HIV-1 and hepatitis C virus (HCV) receiving combination antiretroviral therapy for HIV-1 and interferon alfa with or without ribavirin. In the early symptomatic HIV disease study, asthenia was reported in 69% of patients using zidovudine. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. These side effects may go away during treatment as your body adjusts to the medicine. Gertner E, Thurn JR, Williams DN, et al "Zidovudine-associated myopathy." Side effects and tolerability of post-exposure prophylaxis with zidovudine, lamivudine, and lopinavir/ritonavir: a comparative study with HIV/AIDS patients Chin Med J (Engl). At least 1 case of macular edema was deemed definitively associated with zidovudine in a patient with history of anterior uveitis secondary to syphilis. Lamivudine/Zidovudine Side Effects See also Warning section. SaintMarc T, Partisani M, PoizotMartin I, Bruno F, Rouviere O, Lang JM, Gastaut JA, Touraine JL "A syndrome of peripheral fat wasting (Lipodystrophy) in patients receiving long-term nucleoside analogue therapy." Anemia (hemoglobin less than 8 g/dL) has been reported in 6.4% (CD4 up to 500 using 1500 mg), 1.1% (CD4 up to 500 using 500 mg), 4% (CD4 greater than 200 using 1200 mg), 3% (CD4 greater than 200 using 1500 mg), and 29% (CD4 less than 200 using 1500 mg) of patients using zidovudine. "Tolerability of postexposure prophylaxis with the combination of zidovudine-lamivudine and lopinavir-ritonavir for HIV infection." Drug information provided by: IBM Micromedex. See "Lamivudine Precautions" section. Severe acute exacerbations of hepatitis have been reported in patients with hepatitis B after discontinuation of lamivudine. In an advanced HIV disease study, anorexia (11%) was reported with zidovudine. Commonly reported side effects of lamivudine/zidovudine include: nausea and nausea and vomiting. The most common side effects of DOVATO include: headache; nausea; diarrhea; trouble sleeping; tiredness; anxiety; These are not all the possible side effects of DOVATO. AIDS 12 (1998): 1735-44. Commonly reported side effects include: headache; ear, nose or throat infections; sore throat; malaise (general ill feeling) and fatigue; nausea; diarrhea; cough; fever; chills; muscle and joint pain; This is not a complete list of lamivudine side effects. Aids 14 (2000): 1309-16, 13. O 0, 4. All rights reserved. Med J Aust 150 (1989): 339-40, 19. Pharmacotherapy 26 (2006): 1111-33, 12. Although rare, they may require the immediate termination of the drug and, in some cases, emergency medical intervention. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. In this study, chills, influenza syndrome, and chest pain were reported in less than 5% of patients using zidovudine. Nervous system. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. As of 2019, it is listed by the World Health Organization (WHO) as the first line treatment for adults with HIV/AIDS, with tenofovir/lamivudine/efavirenz as an alternative. In an asymptomatic HIV infection study, anorexia was reported in 19.3% (using 1500 mg) and 20.1% (using 500 mg) of patients using zidovudine. Exacerbation of anemia has been reported in HIV-1/HCV-coinfected patients using zidovudine and ribavirin. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Retrovir (zidovudine)." It is taken by mouth twice a day. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Rabaud C, Burty C, Grandidier M, et al. Although not all of these side effects may occur, if they do occur they may need medical attention. Herskowitz A, Willoughby SB, Baughman KL, et al "Cardiomyopathy associated with antiretroviral therapy in patients with HIV infection: a report of six cases." Tell your doctor if you have: signs of a new infection --fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; N Engl J Med 354 (2006): 251-60. Piacenti FJ "An update and review of antiretroviral therapy." The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cerner Multum, Inc. "UK Summary of Product Characteristics." Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

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