sitagliptin side effects

Before taking ONGLYZA, tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels. Hypersensitivity reactions including anaphylaxis, angioedema, rash, urticaria, cutaneous vasculitis, and exfoliative skin conditions including Stevens-Johnson syndrome [see WARNINGS AND PRECAUTIONS]; hepatic enzyme elevations; acute pancreatitis, including fatal and non-fatal hemorrhagic and necrotizing pancreatitis [see INDICATIONS; WARNINGS AND PRECAUTIONS]; worsening renal function, including acute renal failure (sometimes requiring dialysis) [see WARNINGS AND PRECAUTIONS]; severe and disabling arthralgia [see WARNINGS AND PRECAUTIONS]; bullous pemphigoid [see WARNINGS AND PRECAUTIONS]; constipation; vomiting; headache; myalgia; pain in extremity; back pain; pruritus; mouth ulceration; stomatitis; rhabdomyolysis. Common: constipation. See additional information. Common side effects of Janumet include stomach upset, nausea, vomiting, constipation, diarrhea, headache, weakness, back pain, joint or muscle pain, metallic taste, vitamin B12 deficiency, and cold symptoms. Table 2: It is also available in the fixed-dose combination medication sitagliptin/metformin. Side effects that may occur with Januvia include: Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. ([2015, Aug 28]): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Hypoglycemia) Reported in ≥5% of Patients and More Commonly than in Patients Given Placebo, © Januvia Patient Information is supplied by Cerner Multum, Inc. and Januvia Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Placebo-Controlled Clinical Studies of JANUVIA Monotherapy or Add-on Combination Therapy with Author information: (1)Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China. Postmarketing side effects of sitagliptin reported include: itching; large, fluid-filled blisters; severe allergic reaction (anaphylaxis) skin swelling; rash; hives; inflammation of small and medium-sized vessels in the skin; Stevens-Johnson syndrome; liver enzyme elevations; acute pancreatitis; worsening kidney function ; acute kidney failure Januvia (Sitagliptin) Side Effects Januvia Side Effects: Januvia which is also known as Sitagliptin, is a diabetes medicine that can be consumed orally, which helps to control blood sugar levels. Januvia(Sitagliptin Phosphate) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. In 23 cases symptoms resolved less than 1 month after discontinuation. Our Januvia (sitagliptin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. This medicine does not usually make you put on weight. Two placebo-controlled monotherapy studies, one of 18-and one of 24-week duration, included patients treated with JANUVIA 100 mg daily, JANUVIA 200 mg daily, and placebo. All drugs may cause side effects. Zhou XJ(1), Ding L(1), Liu JX(1), Su LQ(2), Dong JJ(3), Liao L(1). In a pooled analysis of 19 double-blind clinical trials that included data from 10,246 patients randomized to receive sitagliptin 100 mg/day (N=5429) or corresponding (active or placebo) control (N=4817), the incidence of acute pancreatitis was 0.1 per 100 patient-years in each group (4 patients with an event in 4708 patient-years for sitagliptin and 4 patients with an event in 3942 patient-years for control). There were no severe hypoglycemia episodes reported in other studies except in the study involving coadministration with insulin. Manufacturer advises reduce dose to 50 mg once daily if eGFR 30–45 mL/minute/1.73 m 2. Methods: In a single-center open-label trial, 35 patients with inad-equate glycemic control on sitagliptin … Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. "Product Information. You may report side effects to FDA at 1-800-FDA-1088. Pioglitazone, Metformin + Rosiglitazone, or Glimepiride +/-Metformin: Adverse Reactions (Excluding Swelling of the hands and legs can happen when sitagliptin, one of the medicines in STEGLUJAN, is used with rosiglitazone (Avandia ®). In combination with glimepiride, with or without metformin, the overall incidence of clinical adverse reactions with JANUVIA was higher than with placebo, in part related to a higher incidence of hypoglycemia (see Table 3); the incidence of discontinuation due to clinical adverse reactions was similar to placebo. This increase in WBC (of approximately 200 cells/microL vs placebo, in four pooled placebo-controlled clinical studies, with a mean baseline WBC count of approximately 6600 cells/microL) is not considered to be clinically relevant. Some side effects may go away as your body adjusts to the medicine. Background: We investigated the effects of vildagliptin or alogliptin on blood glucose and hemoglobin A1c (HbA1c) in patients with type 2 diabetes inadequately controlled by sitagliptin. Januvia (sitagliptin), a DPP-4 inhibitor, is a diabetes medication used in combination with exercise and diet to improve blood glucose levels in individuals with type 2 diabetes. Check with your doctor immediately if any of the following side effects occur while taking sitagliptin: Sitagliptin Side Effects: What Could Happen as Soon as You Start. ), allergies, pre-existing diseases, and current health conditions (e.g. Read reviews from GoodRx users who have taken Januvia and find the latest news on the drug. The more common side effects that can occur with sitagliptin … With drug discontinuation, supportive treatment and discontinuation of potentially causative agents, a return to baseline levels of renal insufficiency occurred. Serious side effects may include angioedema, low blood sugar, kidney problems, pan When combined with metformin it's … Pregnancy. ).Some health conditions may make you more susceptible to the side-effects of the drug. Taking sitagliptin/metformin with meals can help lessen the common stomach side effects of metformin that usually happen at the beginning of treatment. Efficacy and short-term side effects of sitagliptin, vildagliptin and saxagliptin in Chinese diabetes: a randomized clinical trial. Tell your doctor all prescription and over-the-counter medications you use. Before taking ONGLYZA, tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels. In 22 cases, symptoms appeared within 1 month of starting therapy. It works by controlling levels of insulin which is produced by the body. Find patient medical information for sitagliptin-simvastatin oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Consult your doctor before breastfeeding. Avoid—present in milk in animal studies. Common Questions and Answers about Sitagliptin side effects. [Ref], Postmarketing reports: Worsening renal function[Ref], Between October 2006 and December 2013, thirty-three cases of severe arthralgia have been reported to the FDA Adverse Event Reporting System Database. Read the entire detailed patient monograph for Januvia (Sitagliptin Phosphate). Take sitagliptin tablets once a day. It is taken by mouth. Side Effects. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Subanalysis of a prospective, randomized, controlled study (PRIME-V study) Masaya Koshizaka1,2,KoIshikawa1,2, Ryoichi Ishibashi 2,3,YoshiroMaezawa1,2,KenichiSakamoto2, Daigaku Uchida4, Susumu Nakamura5, Masaya Yamaga 6, … During pregnancy Januvia should be used only when prescribed. In these trials, patients with inadequate glycemic control on a stable dose of the background therapy were randomized to add-on therapy with JANUVIA 100 mg daily or placebo. Ketoacidosis has happened in people who have type 1 diabetes or type 2 diabetes during treatment with STEGLUJAN. Learn about side effects, dosage, generics, and more. Common side effects. Incidences of hypoglycemia are shown in Table 3. Before using Sitagliptin, inform your doctor about your current list of medications, over the counter products (e.g. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Effects of sitagliptin on other medicinal products Digoxin: Sitagliptin had a small effect on plasma digoxin concentrations. Meanwhile, long-acting GLP-1 receptor agonists seemed more effective in reducing FPG. Each case involved the use of 1 or more dipeptidyl peptidase-4 (DPP-4) inhibitors. Some common side effects are: Headache; Loose motion; Stomach pain; Sore throat runny nose; Respiratory tract infection; These side effects are common and go away with time. In those taking sulphonylureas, the risk of low blood sugar is increased. Common (1% to 10%): Nasopharyngitis, upper respiratory infection, pharyngitis, Postmarketing reports: Interstitial lung disease[Ref], There have been postmarketing reports of serious hypersensitivity reactions in patients treated with this drug. 2. Tell your healthcare provider if you have any side effects that continue or get worse. In the 24-week, placebo-controlled factorial study of initial therapy with JANUVIA in combination with metformin, the incidence of hypoglycemia was 0.6% in patients given placebo, 0.6% in patients given JANUVIA alone, 0.8% in patients given metformin alone, and 1.6% in patients given JANUVIA in combination with metformin. Dose adjustments . Sitagliptin/metformin may have other side effects, including: Common side effects when taking JANUMET or JANUMET XR include stuffy or runny nose and sore throat, upper respiratory tract infection, diarrhea, nausea and vomiting, gas, upset stomach, indigestion, weakness, headache, and low blood sugar (hypoglycemia) when used in combination with certain medications, such as a sulfonylurea or insulin. Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. [Ref], Postmarketing reports: Serious hypersensitivity reactions including anaphylaxis, angioedema, rash, urticaria, cutaneous vasculitis, and exfoliative skin conditions including Stevens-Johnson syndrome[Ref], Postmarketing reports: Hepatic enzyme elevations[Ref], There have been postmarketing reports of worsening renal function, including acute renal failure, sometime requiring dialysis. Stomach problems that start later during treatment may be a sign of something more serious. Although not all of these side effects may occur, if they do occur they may need medical attention. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Incidence and Rate of Hypoglycemia* in Placebo-Controlled Clinical Studies when JANUVIA was used In a 24-week study of initial therapy with JANUVIA in combination with pioglitazone, there were no adverse reactions reported (regardless of investigator assessment of causality) in ≥5% of patients and more commonly than in patients given pioglitazone alone. Table 3: Common side effects of Januvia include upper respiratory tract infection, headache, abdominal pain, nausea, and diarrhea. T1 LADA. On Levemir twice a day and NovoRapid for Bolus. Although not all of these side effects may occur, if they do occur they may need medical attention. However, many people have no side effects or only have minor side effects. It is taken by mouth. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Manufacturer advises reduce dose to 50 mg once daily if eGFR 30–45 mL/minute/1.73 m 2. iam a doctor and i have dignosed sudden dibaties.i want ask about sitagliptin is a short acting or lond acting drug. drugs a-z list Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. It’s used with diet and exercise to treat type 2 diabetes. Slower passage of food from the stomach to the colon can lead to heaviness, improper digestion and pains in the digestive tract, especially in the colon. Call your doctor for medical advice about side effects. Merck got these two drugs approved by the U.S. Food and Drug Administration (FDA) in 2006 and 2007 and since then has made a huge amount of money. Read More. pregnancy, upcoming surgery, etc. Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. In an additional, 24-week, placebo-controlled factorial study of initial therapy with sitagliptin in combination with metformin, the adverse reactions reported (regardless of investigator assessment of causality) in ≥5% of patients are shown in Table 2. The most common side effects of sitagliptin include: upper respiratory infection; stuffy or runny nose and sore throat; headache; stomach upset and diarrhea; STEGLUJAN may have other side effects including swelling of the hands or legs. There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with sitagliptin or any other anti-diabetic drug. The most common side effects of ertugliflozin include genital yeast infections and changes in urination. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Common (1% to 10%): Hypoglycemia (when used in combination with insulin or sulfonylurea)[Ref], Common (1% to 10%): Abdominal pain, nausea, diarrhea, constipation, gastroenteritis, Postmarketing reports: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, vomiting, mouth ulceration, stomatitis[Ref], In a pooled analysis of 19 trials (sitagliptin 100 mg/day, n=5429; active control or placebo, n=4817), the incidence of acute pancreatitis was in 0.1 per 100 patient-years in each group (4 patients in each group)[Ref]. Avoid—toxicity in animal studies. The most common side-effects are feeling sick (nausea), headache, and nose or … Cerner Multum, Inc. "Australian Product Information." Along with its needed effects, sitagliptin may cause some unwanted effects. In the study of JANUVIA as initial therapy with pioglitazone, one patient taking JANUVIA experienced a severe episode of hypoglycemia. If you have unusual or sudden stomach problems, talk with your doctor. The most common side effects of sitagliptin are: upper respiratory tract infection and; headache. Common side effects include headaches, swelling of the legs, and upper respiratory tract infections. US Food and Drug Administration "FDA Drug Safety Communication: FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain or heartburn. iam a doctor and i have dignosed sudden dibaties.i want ask about sitagliptin is a short acting or lond acting drug. STOP taking Januvia and contact a doctor immediately if you notice any of the following serious side effects: Severe and persistent pain in the abdomen (stomach area) which might reach through to your back with or without nausea and vomiting, as these could be … Low Blood Sugar or Hypoglycemia Some side effects may not be reported. Januvia belongs to the group of diabetes medications known as DPP-4 inhibitors. * Adverse reactions of hypoglycemia were based on all reports of symptomatic hypoglycemia; a concurrent glucose measurement was not required; intent-to-treat population. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. No significant difference exists in the occurrence of hypoglycemia between placebo and sitagliptin. Januvia (sitagliptin) is a brand-name prescription medication. Some patients have experienced the following side effects while taking sitagliptin in combination with a sulphonylurea and metformin: Very common (may affect more than 1 in 10 people): low blood sugar. O 0. Learn about side effects, dosage, generics, and more. Pregnancy may cause or worsen diabetes. Janumet may trigger all of the same side effects because it also contains sitagliptin. Sitagliptin can cause several side effects and the severity differs from person to person. Side Effects What are the side effects of Janumet (Metformin And Sitagliptin)?. Side effect Data for drug Placebo Labels 1: 2: Asthenia : uncommon, common x: x: … Side-effects, further information. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. Discussion. The most common side effects of sitagliptin are: upper respiratory tract infection and; headache. Sitagliptin & Simvastatin - Get up-to-date information on Sitagliptin & Simvastatin side effects, uses, dosage, overdose, pregnancy, alcohol and more. Serious side effects can happen in people who take ONGLYZA, including inflammation of the pancreas (pancreatitis), which may be severe and lead to death. [See WARNINGS AND PRECAUTIONS]. metformin, Trulicity, Victoza, Tresiba, Lantus, Levemir. A concurrent blood glucose measurement was not required although most (74%) reports of hypoglycemia were accompanied by a blood glucose measurement ≤70 mg/dL. Across clinical studies, the incidence of laboratory adverse reactions was similar in patients treated with JANUVIA 100 mg compared to patients treated with placebo. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Headache and other aches or pains: Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. Three patients had hypoglycaemia, whereas each of the remaining patients had worsening of allergic reaction, cough, weight loss, drowsiness, increase in creatinine level, swelling of the leg, and bloating and one patient just could not tolerate sitagliptin with no specific reason given. Available from: URL: http://www.fda.gov/downloads/Drugs/DrugSafety/UCM460038.pdf." Sitagliptin oral tablet doesn’t cause drowsiness, but it can cause other side effects. Available for Android and iOS devices. Five placebo-controlled add-on combination therapy studies were also conducted: one with metformin; one with pioglitazone; one with metformin and rosiglitazone; one with glimepiride (with or without metformin); and one with insulin (with or without metformin). Drug class: dipeptidyl peptidase 4 inhibitors, Blistering, peeling, loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips. Dosage. I. Irish-Chris Member. This is not a complete list of side effects and others may occur. INFREQUENT side effects If experienced, these tend to have a Severe expression i . ), allergies, pre-existing diseases, and current health conditions (e.g. Tell your doctor if you have serious side effects of Januvia including pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate), urinating less than usual or not at all, swelling, weight gain, shortness of breath, or severe skin reaction (fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads [especially in the face or upper body] and causes blistering and peeling). The recommended dose of sitagliptin is 100 mg once daily.. Precautions. Description: Sitagliptin inhibits dipeptidyl peptidase IV (DPP-IV) enzyme resulting in prolonged active incretin levels.Incretin hormones, including glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), regulate glucose homeostasis by increasing insulin synthesis and release from pancreatic β-cells and decreasing glucagon secretion from pancreatic α-cells. Januvia and the similar drug Janumet are two medications made by Merck to treat type 2 diabetes along with diet and exercise changes. Regardless of Investigator Assessment of Causality*. Sitagliptin side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Last updated on May 30, 2020. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. A subset of these reports involved patients with renal insufficiency, some who were prescribed inappropriate doses of this drug. In conclusion, for obese/overweight patients, sitagliptin might exert a less potent effect regarding HbA 1C, FPG, PPG, and weight reduction than GLP-1 receptor agonists; however, there was no difference in hypoglycemic risk. Avoid—toxicity in animal studies. Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Learn more about Sitagliptin & Simvastatin [Ref], Postmarketing reports: Arthralgia, myalgia, extremity pain, back pain, osteoarthritis, rhabdomyolysis[Ref], The most commonly reported adverse events included upper respiratory tract infection, nasopharyngitis, and headache. Serious side effects are although rare, yet it is important to know that some patients have suffered from low blood sugar, pancreatitis, kidney abnormalities, and allergic reactions while taking this drug. Receiving Combination Therapy (and Greater than in Patients Receiving Metformin alone, Sitagliptin Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. In the 24-week study of patients receiving JANUVIA as add-on therapy to insulin (with or without metformin), there were no adverse reactions reported regardless of investigator assessment of causality in ≥5% of patients and more commonly than in patients given placebo, except for hypoglycemia (see Table 3). Discontinue if symptoms of acute pancreatitis occur such as persistent, severe abdominal pain. Learn about Januvia (sitagliptin), potential side effects, proper use and dosing, and popular alternatives. Side effects that may occur with Januvia include: Many people using Januvia do not have serious side effects. Breast feeding. In a pooled analysis of the two monotherapy studies, the add-on to metformin study, and the add-on to pioglitazone study, the overall incidence of adverse reactions of hypoglycemia was 1.2% in patients treated with JANUVIA 100 mg and 0.9% in patients treated with placebo. Check with your doctor immediately if any of the following side effects occur while taking sitagliptin: Some side effects of sitagliptin may occur that usually do not need medical attention. Side-effects, further information. Through Week 54, the overall incidence of hypoglycemia was 3.9% in patients given add-on JANUVIA and 1.0% in patients given add-on placebo. alone, and Placebo)*. Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. Life-threatening (Report these to your healthcare provider right away. Merck & Company Inc, West Point, PA. 3. as Add-On Therapy to Glimepiride (with or without Metformin) or Insulin (with or without Metformin), The most common side effects of sitagliptin include upper respiratory tract infection, stuffy or runny nose and sore throat, headache, and stomach upset and diarrhea. Dose adjustments . Side Effects What are the side effects of Janumet (Metformin And Sitagliptin)?. In controlled clinical studies as both monotherapy and combination therapy with metformin, pioglitazone, or rosiglitazone and metformin, the overall incidence of adverse reactions, hypoglycemia, and discontinuation of therapy due to clinical adverse reactions with JANUVIA were similar to placebo. No clinically meaningful changes in vital signs or in ECG (including in QTc interval) were observed in patients treated with JANUVIA. Some patients have experienced the following side effects while taking sitagliptin and pioglitazone: Common: flatulence, swelling of the hands or legs. The clinical significance of this added increase in serum creatinine relative to placebo is not known. Regardless of Investigator Assessment of Causality. Discontinue if symptoms of acute pancreatitis occur such as persistent, severe abdominal pain. Sitagliptin was associated with side effects in eleven patients. In an additional, 30-week placebo-controlled, study of patients with type 2 diabetes inadequately controlled with metformin comparing the maintenance of sitagliptin 100 mg versus withdrawal of sitagliptin when initiating basal insulin therapy, the event rate and incidence of documented symptomatic hypoglycemia (blood glucose measurement ≤70 mg/dL) did not differ between the sitagliptin and placebo groups. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Side Effects What are the side effects of Januvia (Sitagliptin)?. Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Janumet (metformin and sitagliptin) is a prescription medication used to reduce blood glucose (sugar) levels in individuals with type 2 diabetes. Other important side effects of sitagliptin include: abdominal pain, nausea and; diarrhea. Your doctor may change your diabetes treatment during pregnancy. Following administration of 0.25 mg digoxin concomitantly with 100 mg of sitagliptin daily for 10 days, the plasma AUC of digoxin was increased on average by 11 %, and the plasma C max on average by 18 %. The most common side effect of sitagliptin is headaches. In the 24-week study of patients receiving JANUVIA as add-on combination therapy with metformin, there were no adverse reactions reported regardless of investigator assessment of causality in ≥5% of patients and more commonly than in patients given placebo. Common side effects. throat irritation

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