Ketoacidosis is a more common occurrence with type 1 diabetes. See below for a comprehensive list of adverse effects. The right dosage will provide benefit without harm. [Ref], Frequency not reported: Acute painful peripheral neuropathy[Ref], Weight gain can occur with insulin use; it is believed to be due to the anabolic effects of insulin and the decrease in glycosuria.[Ref]. Insulin increases the intracellular transport of phosphate, which often results in hypophosphatemia during treatment of DKA. NovoLIN N (insulin isophane (NPH))." Tell your You may report them to the FDA. Some pills to treat diabetes include: Biguanides. These side effects may go away during treatment as your body adjusts to the medicine. [Ref], Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site, Very rare (less than 0.01%): Anaphylactic reactions, Postmarketing reports: Severe, life-threatening, generalized allergy, including anaphylaxis[Ref]. "Product Information. [Ref], Frequency not reported: Formation of anti-insulin antibodies[Ref], Frequency not reported: Sodium retention and edema[Ref], Insulin may cause sodium retention and edema, especially with intensified insulin therapy. Lilly, Eli and Company, Indianapolis, IN. Side effects not requiring immediate medical attention. Cerner Multum, Inc. "UK Summary of Product Characteristics." Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Medically reviewed by Drugs.com. The timing of hypoglycemia generally reflects the time-action profile of the administered insulin, however, the time action profile of any insulin may vary considerably in different individuals or at different times in the same individual depending on dose, site of injection, blood supply, temperature, and physical activity. advice about side effects. Hypokalemia and hypomagnesemia has been reported, particularly in patients treated for diabetic ketoacidosis (DKA). "Product Information. Insulin increases the intracellular transport of phosphate, which often results in hypophosphatemia during treatment of DKA. Drugs and Supplements Insulin Human Regular (Injection Route) Description and Brand Names. Applies to insulin isophane: subcutaneous suspension, Frequency not reported: Sodium retention and edema[Ref], Insulin may cause sodium retention and edema, especially with intensified insulin therapy. Humulin R (insulin regular)." Over the long-term, improved glycemic control decreases the risk for neuropathy. Lipodystrophy includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissues). If you have questions about side effects, call your doctor. US Brand Name. These drugs boost the way insulin works in the body. Some of the dosage forms listed on this page may not apply to the brand name NPH Insulin.. For the Consumer What are the side effects? Insulin aspart should be used along with an intermediate or long-acting insulin. "Product Information. O 0, 3. Below is a list of medications that can interact with insulin regular (human). Lantus (insulin glargine) is a man-made injectable form of insulin used to regulate sugar (glucose) levels in type 1 and type 2 diabetes. Call your doctor for medical These usually resolve in a few days to a few weeks; rotation of the injection site reduces the risk of these reactions developing. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. Novo Nordisk Pharmaceuticals Inc, Princeton, NJ. Side effects not requiring immediate medical attention. Hypokalemia, which is due to a shift in potassium from the extracellular to the intracellular space, occurs with all insulins. It is also used along with glucose to treat high blood potassium levels. We comply with the HONcode standard for trustworthy health information -. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. metformin, Trulicity, Victoza, Tresiba, Lantus, Levemir, Humalog, sodium bicarbonate, Novolog, Basaglar. Children may be more sensitive to the side effects of this drug, especially low blood sugar. Cerner Multum, Inc. "Australian Product Information." Cerner Multum, Inc. "UK Summary of Product Characteristics." Insulin is a medication prescribed to treat type 1 diabetes and type 2 diabetes mellitus. Available for Android and iOS devices. Our Lantus (insulin glargine [rdna origin]) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Commonly reported side effects of insulin regular include: hypoglycemia. These reactions are becoming rare (less than 1% of patients) due to the use of purer forms of pork insulin or biosynthetic human insulin. Common side effects of Lantus include decreased blood sugar, injection site reactions, water retention in the joints, and weight gain. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Side effects, such as upset stomach and decreased appetite, are generally mild. Other factors such as changes in food intake (timing of meals, amount or type of food) and concomitant medications will also affect the risk of hypoglycemia. For instance, some can interfere with how well a drug works, while others can cause increased side effects. Localized reactions have been reported with metacresol, which is an excipient in many insulin products. Like all medications, you need to take insulin in the right amounts. Keep in mind that most of the side effects of insulin are actually the result of inaccurate doses and improper injection practices. Rapid-acting insulin starts to work almost immediately after you inject it. SLIDESHOW … In situations in which not enough insulin is available to control blood glucose, hyperglycemia, diabetic ketoacidosis, and hyperosmolar hyperglycemic non-ketotic syndrome may occur. Some side effects may not be reported. Side Effects. Basal insulin is the insulin that keeps your blood sugar steady all day. This is not a complete list of side effects and others may occur. In some instances these reactions have been caused by other factors such as irritants in a skin cleansing agent or poor injection technique. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Call your doctor for medical advice about side effects. [Ref], Increases in titers of anti-insulin antibodies that react with human insulin have been observed; some data indicates the increase is transient. The former can result in high blood sugar, or hyperglycemia. Drug class: basal insulin; Drug form: liquid solution given by subcutaneous injection; Like other drugs, Tresiba can cause side effects. Other Possible Insulin Side Effects. Common side effects of insulin. We comply with the HONcode standard for trustworthy health information -. What are the side effects of the diabetes drug insulin? Cerner Multum, Inc. "Australian Product Information." Can regular and lispro insulin (Humalog) be mixed? Last updated on Nov 16, 2020. Over the long-term, improved glycemic control decreases the risk for diabetic neuropathy. [Ref], Adverse reactions reported with this insulin include hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, weight gain, and edema[Ref], Rare (less than 0.1%): Insulin resistance, Frequency not reported: Hypokalemia, hyperglycemia, diabetic ketoacidosis, hyperosmolar hyperglycemic non-ketotic syndrome, hypomagnesemia, hypophosphatemia. Other factors such as changes in food intake (timing of meals, amount or type of food) and concomitant medications will also affect the risk of hypoglycemia. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Hypersensitivity reactions have included both local and systemic reactions. Humulin N (insulin isophane)." Hypoglycemia is the most common adverse reaction of all insulin therapies. 2. Check with your doctor immediately if any of the following side effects occur while taking insulin regular: Some side effects of insulin regular may occur that usually do not need medical attention. A person with diabetes who has hyperglycemia frequently or for long periods of time may suffer damage to the blood vessels, nerves, and organs. The timing of hypoglycemia generally reflects the time-action profile of the administered insulin, however, the time action profile of any insulin may vary considerably in different individuals or at different times in the same individual depending on dose, site of injection, blood supply, temperature, and physical activity. Low blood sugar (hypoglycemia) is a side effect of all forms of insulin. It puts people at risk for: The clinical significance of these antibodies is unknown; it does not appear to cause deterioration in glycemic control. [Ref], Uncommon (0.1% to 1%): Lipodystrophy[Ref], Long-term use of insulin can cause lipodystrophy at the site of repeated insulin injections. Generalized allergy to insulin may present as a whole body rash, dyspnea, wheezing, hypotension, tachycardia, or diaphoresis. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Consult your doctor before taking Lantus if pregnant or breastfeeding. [Ref], Frequency not reported: Acute painful peripheral neuropathy[Ref], Weight gain can occur with insulin use; it is believed to be due to the anabolic effects of insulin and the decrease in glucosuria.[Ref]. It may cause you to hang on to fluids in your body, which can lead to swelling. Call your doctor for medical advice about side effects. Also, each type of insulin has its own profile of possible side effects. A slow erosion of health is the silent, insidious danger of not taking medications as necessary for type 1 or type 2 diabetes. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This is not a complete list of side effects and others may occur. metformin, Trulicity, Victoza, Tresiba, Lantus, Levemir, Novolog, Basaglar, Toujeo, insulin regular. [Ref], Acute painful peripheral neuropathy has been reported with insulin initiation and glucose control intensification. Drug interactions (drug on drug side effects): Beta-blockers, clonidine and reserpine may mask some of the signs and symptoms of hypoglycemia. You may also report side effects at https://www.fda.gov/medwatch. Drug information provided by: IBM Micromedex. Insulin is used to treat a number of diseases including diabetes and its acute complications such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Novo Nordisk Pharmaceuticals Inc, Princeton, NJ. There are several types, preparations, and dosage amounts of insulin. [Ref], Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site, Very rare (less than 0.01%): Anaphylactic reactions[Ref], Hypersensitivity side effects have included both local and systemic reactions. In situations in which not enough insulin is available to control blood glucose, hyperglycemia, diabetic ketoacidosis, and hyperosmolar hyperglycemic non-ketotic syndrome may occur. This medication may be available under multiple brand names and/or in several different forms. These side effects may go away during treatment as your body adjusts to the medicine. "Product Information. HumuLIN R; HumuLIN R U-100 ; NovoLIN R; Descriptions. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site, redistribution or accumulation of body fat. 1. These usually resolve in a few days to a few weeks; rotation of the injection site reduces the risk of these reactions developing. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. You may report side effects to FDA at 1-800-FDA-1088. Below, we describe certain interactions and the drugs … Some side effects may not be reported. NovoLIN R (insulin regular)." Combination use with thiazolidinediones has resulted in fluid retention which has led to or exacerbated heart failure. There are various side effects that occur from insulin. Combination use with thiazolidinediones has resulted in fluid retention which has led to or exacerbated heart failure. Medically reviewed by Drugs.com. These side effects may go away during treatment as your body adjusts to the medicine. Applies to insulin isophane: subcutaneous suspension, subcutaneous suspension pen-injector. O 0, 3. Regular insulin side effects. Along with its needed effects, insulin regular may cause some unwanted effects. You may report side effects to FDA at 1-800-FDA-1088. Last updated on Nov 16, 2020. Along with its needed effects, a medicine may cause some unwanted effects. Some side effects of liraglutide may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Note: This document contains side effect information about insulin isophane. Which type of insulin has the longest duration of action? 1. O 0. Although not all of these side effects may occur, if they do occur they may need medical attention. NovoMix 30: Insulin is a naturally occurring hormone made by the pancreas that helps our body use or store the glucose (sugar) it gets from food. [Ref], Transitory, reversible ophthalmologic refraction disorder and worsening of diabetic retinopathy has been reported with insulin initiation and glucose control intensification. O 0. Get emergency medical help if you have signs of insulin allergy: redness, swelling, sweating, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat. Other side effects include: weight gain. Lipodystrophy includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissues). Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Some of the dosage forms listed on this page may not apply to the brand name NPH Insulin. [Ref], Frequency not reported: Transitory, reversible ophthalmologic refraction disorder, worsening diabetic neuropathy[Ref], Common (1% to 10%): Injection site hypertrophy, Frequency not reported: Injection site reactions[Ref], Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching have occurred. Hypokalemia and hypomagnesemia has been reported, particularly in patients treated for diabetic ketoacidosis (DKA). Treatment involves hospitalization, IV fluids and insulin. Insulin is one of many hormones that help the body turn the food we eat into energy. Side effects include nausea, hunger, headache, blurred vision, irritability, heart palpitations, and tremors. The drug interactions can vary — some cause the insulin to work less well, while others cause side effects to become more severe. Over the long-term, improved glycemic control decreases the risk for diabetic neuropathy. It only works for 2 to 4 hours. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Consumer; Side effects; Professional; FAQ; Note: This document contains side effect information about insulin isophane. However, some patients experience an interference with … Call your doctor or get medical [Ref], The most common adverse reactions reported with this insulin include hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, weight gain, and edema. Insulin was formerly used in a psychiatric treatment called insulin shock therapy.. Side effects Allergy. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Weight gain has been reported and has been attributed to the anabolic effects of insulin and the decrease in glucosuria. Biguanides (Metformin) Biguanides lower blood sugar by decreasing the amount of sugar made by the liver, thus decreasing the need for insulin. Lilly, Eli and Company, Indianapolis, IN. Unfortunately, insulin can cause weight gain, interactions with other medications, headaches, and nausea. The change can have upsides, particularly for patients who have been on a complicated regimen of three or four drugs, with lots of side effects. The main side effects of insulin have to do with taking too little or too much of the drug. Low blood sugar Changing to insulin can actually be a lot better. Check with your doctor immediately if any of the following side effects occur: More common. 4. SLIDESHOW … Insulin human regular is a short-acting type of insulin. Drug information provided by: IBM Micromedex. 4. You may report them to the FDA. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. True allergy to insulin has been rare, and sensitization was usually associated with specific animal proteins in bovine and less pure forms of porcine insulins. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to insulin regular: injectable solution, intravenous solution, subcutaneous solution, Transitory, reversible ophthalmologic refraction disorder and worsening of diabetic retinopathy has been reported with insulin initiation and glucose control intensification. They usually occurred within the first two weeks of therapy and then disappear. Our Humulin R (insulin (human recombinant)) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Common side effects of insulin include hypoglycemia, headache, weight gain, rash, itching, flu-like symptoms, lipoatrophy, and reaction at the site of injection. NPH Insulin Side Effects. For people with diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. [Ref], Common (1% to 10%): Injection site hypertrophy, Frequency not reported: Injection site reactions[Ref], Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching have occurred. Last updated on April 26, 2020. Signs of an allergic reaction, like rash; Thick skin, pits, or lumps where the injection was given. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Some people with type 2 diabetes can benefit from using both medication and insulin. Insulin is the oldest medication for diabetes and is usually well tolerated by most people. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Available for Android and iOS devices. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Hypokalemia, which is due to a shift in potassium from the extracellular to the intracellular space, occurs with all insulins. Generic Name: insulin isophane Medically reviewed by Drugs.com. Most minor reactions to insulin at the injection site resolve in a few days to a few weeks. [Ref], Acute painful peripheral neuropathy has been reported with insulin initiation and glucose control intensification. No diabetes medication is free from side effects, but these are some of the worst offenders. Hypoglycemia is the most common adverse reaction of all insulin therapies. Local reactions have presented as erythema, swelling, heat, or subcutaneous nodules. You may report side effects to the FDA at 1-800-332-1088. Warnings, precautions, and drug interactions should be reviewed prior to taking insulin. When taken with great care and careful management, insulin is a critical part of what keeps you alive and healthy. ... (such as diet and medications including insulin). Continued. Over the long-term, improved glycemic control decreases the risk for neuropathy. Long-Term Dangers. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
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