Hydrea may interact with didanosine, stavudine, or an interferon. Dosage for Hydrea. HYDROXYUREA is a chemotherapy drug. Hydrea (hydroxyurea) is available in 500 mg tablets. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Hydrea(Hydroxyurea) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. While patients receiving hydroxyurea therapy did see weight gain, they also saw improvement in both aerobic cardiovascular efficiency and anaerobic muscular performance, … received an overall rating of 5 out of 10 stars from 6 reviews. All rights reserved. numbness, tingling, or burning pain in your hands or feet; sudden chest pain, wheezing, dry cough, feeling short of breath; Risks with concomitant use of antiretroviral drugs [see. Our Hydrea Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. loss of appetite, nausea, vomiting, diarrhea, constipation, sores in the mouth, skin rash, Common side effects of this drug are: Skin changes, muscle weakness, pains and weakness, especially on walking or climbing stairs. Because these reactions are reported voluntarily froma population of uncertain size, it is not always possible to reliably estimate their frequency. Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and essential thrombocythemia. More common side effects. It is taken by mouth. You will find a full list in the manufacturer's information leaflet supplied with your treatment. Adverse reactions observed with combined hydroxyurea and irradiation therapy are similar to those reported with the use of hydroxyurea or radiation treatment alone. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. The safety and effectiveness of Hydrea in pediatric patients has not been established. It affects other cells as well. ).Some health conditions may make you more susceptible to the side-effects of the drug. Summary: Side effects are reported by people who take Hydroxyurea. Hydroxyurea can temporarily lower the number of white blood cells in your blood which increases the chance of getting an infection. Tell your doctor if you are also using antiviral medicine or an interferon. Hydroxyurea is an oral medicene that is prescribed to patients suffering from chronic myelogenous leukemia, acute myelogenous leukemia, sickle-cell disease, ovarian cancer, cervical cancer, and polycythemia vera.. eHealthMe makes it possible for everyone to run their own clinical trial. The agent was used for many years to treat people with certain malignancies before being used for sickle cell disease. This survey is being conducted by the WebMD marketing sciences department. Hi Isabel, I was diagnosed with PV 12 years ago and have been taking Hydroxy for the last 5 years. It interferes with DNA activity in your body - slowing down the activity of hemopoietic stem cells. Side effects of Hydroxyurea / Hydroxycarbamide. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies, capsule, pink/turquoise, imprinted with HYDREA 830, HYDREA 830, capsule, turquoise, imprinted with DROXIA 6335, DROXIA 6335, capsule, pink/purple, imprinted with barr, 882, capsule, green/pink, imprinted with 724, par, capsule, purple, imprinted with DROXIA 6336, DROXIA 6336, capsule, orange, imprinted with DROXIA 6337, DROXIA 6337, green/peach, imprinted with 54 072, 54 072. Side effects of hydroxyurea include: Nausea; Vomiting ; Constipation; Diarrhea; Mucositis; Acute pulmonary reactions (rare) Genetic mutation (long-term use) Secondary leukemia (long-term use) Elevated BUN, Cr ; Excess uric acid in the blood (hyperuricemia) Renal failure; Rash; Darkened patches of skin (hyperpigmentation) Skin ulcer; Gangrenous disorder; Upset stomach Select a condition to view a list of medication options. Because of the drug's effects on cells, Before using Hydroxyurea, inform your doctor about your current list of medications, over the counter products (e.g. Hydroxyurea (Droxia, Siklos) is used to reduce the frequency of painful crises and reduce the need for blood transfusions in adults and children 2 years of age and older with sickle cell anemia (an inherited b… See additional information. Hydroxyurea Capsule : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage. Common side effects of Hydrea include: nausea, vomiting, upset stomach, diarrhea, constipation, skin changes such as peeling or discoloration, flu-like symptoms, hair loss, rash, headache, dizziness, drowsiness, or ; weight gain. Hydroxyurea may cause other cancers (such as secondary leukemia, skin cancer). CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Treating Opioid Use Disorder With Medications, Constipated? Common side effects include bone marrow suppression, lack of appetite, vomiting, diarrhea, mouth and stomach ulcers, loss of toenails and/or hair coat. Tell your doctor all Dr. Bart Scott from Seattle Cancer Care Alliance discusses research for this treatment and the long-term safety of this medication. Things to remember when you fill your prescription. Do not use in pets that are allergic to it, or in pregnant pets unless absolutely necessary. The table below contains some of the most common side-effects associated with hydroxyurea, although not everyone experiences these. Platelet depression (<100,000 cells/mm3) has occurred in the presence of marked leukopenia. This is not a complete list of side effects and others may occur. Low Levels Of A Type Of White Blood Cell Called Neutrophils 3. Avoid prolonged sun exposure, tanning booths, and sunlamps. Should I avoid certain foods while taking hydroxyurea? In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks. Dose has varied over the years, currently 8 x 500mg tablets per week. The study is created by eHealthMe based on 9,660 reports from the FDA, and is updated regularly. Call your doctor for medical advice about side effects. pregnancy, upcoming surgery, etc. Jakafi vs. Hydroxyurea: side effect and effectiveness comparison - a phase IV clinical study. Copyright © 2021 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. vitamins, herbal supplements, etc. Some of the unwanted effects bear on the fact that HU is teratogenic, and potentially mutagenic and carcinogenic. Nausea 6. In addition to treating cancer, Droxia, another oral form of hydroxyurea is used in the management of sickle cell disease. The lowest GoodRx price for the most common version of hydroxyurea is around $11.01, 77% off the average retail price of $48.69. An Infection 2. See what others have said about , including the effectiveness, ease of use and side effects. Common side effects of Hydrea include. Hydroxyurea can decrease white blood cells, hemoglobin, and platelets. Interferon-α is used in place … Does hydroxyurea interact with other medications? Based on the doses used in sickle cell anemia, the side effects of hydroxyurea therapy are relatively mild. These effects primarily include bone marrow depression (anemia and leukopenia), gastric irritation, and mucositis. Please let your physician know if you experience any of the following: Very common hydroxyurea side-effects (these affect more than 1 in 10 people) Read the entire FDA prescribing information for Hydrea (Hydroxyurea). Common side effects include death among females and death among males. Tell your doctor about all your current medicines and any medicine you start or stop using. It can also lower the number of platelets, which are necessary for proper blood clotting. No side effects at all. ), allergies, pre-existing diseases, and current health conditions (e.g. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 48,912 people who take Jakafi and Hydroxyurea, and is updated regularly. Hydroxyurea (Hydrea) is used alone or with other medications or radiation therapy to treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of the white blood cells) and certain types of head and neck cancer (including cancer of the mouth, cheek, tongue, throat, tonsils, and sinuses). © 2005 - 2021 WebMD LLC. Hair loss, mouth sores, and increased risk of infection associated with chemotherapy are rarely seen. Hydrea (hydroxyurea) is available in 500 mg … 12 Medicines That Could Help. One of the hydroxyurea side effects is weight gain, although it’s considered one of the less common side effects of hydroxyurea. Headache 5. Some people can be on Hydrea® (hydroxyurea) for an extended period of time. Drowsiness 4. Vomiting A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The following clinically significant adverse reactions are described in detail in other labeling sections: The following adverse reactions have been identified during post-approval use of HYDREA. Selected from data included with permission and copyrighted by First Databank, Inc. Almost all patients receiving an adequate course of combined hydroxyurea and irradiation therapy will demonstrate concurrent leukopenia. skin changes such as peeling or discoloration. This drug can also cause other side effects. medications and supplements you use. What should I know regarding pregnancy, nursing and administering hydroxyurea to children or the elderly? If a negative reaction occurs, please call your veterinary office. Common side effects may include: loss of appetite, nausea; constipation, diarrhea; low blood cell counts; bleeding; or mouth sores. Dosage depends on the Side Effects. Take as directed by your doctor or follow the direction … The exact mechanism by which hydroxyurea works to treat sickle cell disease is not understood. Hydrea (hydroxyurea) is an antineoplastic (anti-cancer) agent used to treat melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and primary squamous cell (epidermoid) carcinomas of the head and neck. Protect your skin from the sun. In this setting, hydroxyurea is used to potentiate the effect of these drugs (Moore et al., 2000). Diarrhea 3. Some medicines can increase your risk of serious side effects while taking hydroxyurea. HYDREA may potentiate some adverse reactions usually seen with irradiation alone, such as gastric distress and mucositis. problem being treated; the prescribing doctor will determine dosage. This medicine is used to treat certain types of leukemias and head and neck cancer. WebMD does not provide medical advice, diagnosis or treatment. You may report side effects to FDA at 1-800-FDA-1088. Low Levels Of White Blood Cells If experienced, these tend to have a Less Severe expression 1. Decreased Appetite 2. the benefits should be weighed against the possible harm to the infant if the © Hydrea Patient Information is supplied by Cerner Multum, Inc. and Hydrea Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. The most concerning potential side-effect of hydrea is development of secondary leukemia or myelodysplasia; however, data are not conclusive. Hydrea is available in generic form. Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of … home Summary: We compare the side effects and drug effectiveness of Jakafi and Hydroxyurea. Known side effects include: bone marrow suppression (drop in white blood cell, red blood cell and platelet counts), anorexia, nausea, vomiting, diarrhea, constipation, sores in the mouth, skin rash, It can be as a direct effect of hydroxyurea or from a parvovirus infection due to the immunosuppression produced by hydroxyurea which in turn causes bone marrow suppression or from vitamin B12 deficiency. Absence or decreased sperms in semen (azoospermia or oligospermia) Reduced hunger, feeling sick, loose motions, constipation, stomach pain. Read the entire detailed patient monograph for Hydrea (Hydroxyurea). drugs a-z list If experienced, these tend to have a Severe expression 1. Other non-specific side effects include: Constipation; Weight gain; Hyperpigmented patches on the skin; Anorexia; Breathlessness Hydrea should not be used in pregnant women; breast milk may contain the drug so That does not mean these things will happen, but it is a known risk. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. What are the long-term effects of this therapy? drug is administered to breastfeeding women. spontaneous hemorrhages and increase in blood platelets, low levels of a type of white blood cell called neutrophils, x-ray results showing lung tissue changes, increased uric acid in the body resulting in kidney disease, a toxic effect on the central nervous system, which consists of the brain and spinal cord, inflammation of blood vessels in the skin, a type of inflammation of the lung called interstitial pneumonitis, a condition where there is formation of fibrous tissue in the lung called pulmonary fibrosis, inflammation of the liver called hepatitis, systemic lupus erythematosus, an autoimmune disease, a type of bumpy skin rash called a maculopapular rash, abnormally large red blood cells called macrocytosis, a type of stomach irritation called gastritis, a feeling of general discomfort called malaise. Hydroxyurea is a chemotherapy agent with potent effects on the bone marrow. The side effects reported most often by adults with sickle cell anemia participating in studies of hydroxyurea included hair loss, skin rash, fever, stomach and/or bowel disturbances, weight gain, bleeding, virus infection, and discolored nails (melanonychia), but these were equally common in people getting a placebo (sugar pill). It comes as a capsule that is usually taken once in a day. Hydrea is teratogenic and is not given to women of child bearing potential. Hydroxyurea is given by mouth and is used off label to treat certain cancers in cats and dogs. A study published in Clinical Science explored weight gain and body composition in patients with sickle cell anemia. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. 5 Treatment withdrawal is usually necessary and symptoms may take weeks to months to resolve.1,5 Nail pigmentation has been reported in up to 5% of patients taking hydroxyurea; pigmentation typically occurs weeks to years after starting therapy.1,8,11 Vasculitic toxicities, including vasculitic … It is also used to control the painful crises of sickle cell anemia. Other drugs may affect hydroxyurea, including prescription and over-the-counter medicines, vitamins, and herbal products. Serious side effects of Hydrea include: anemia, myelosuppression, and ; leukemia. Hydroxyurea and are likely due to the chronic cumulative toxicity of hydroxyurea or one of its metabolites. Rashes on the face or parts of the body. The primary side-effect of hydroxyurea is suppression of blood counts, particularly the white blood cells (neutropenia) and platelets (thrombocytopenia). See additional information. This medicine slows down the growth of cancer cells in the body and can reduce the need for blood tranfusion.
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